Annotation Detail

Information
Associated Genes
ALDH1A2
Associated Variants
ALDH1A2 UNDEREXPRESSION ( ENST00000249750.9 )
ALDH1A2 UNDEREXPRESSION ( ENST00000249750.9 )
Associated Disease
head and neck squamous cell carcinoma
Source Database
CIViC Evidence
Description
FaDu (a high ALDH1A2 expression cell line) and Cal27 (a low expression cell line) were treated with all-trans retinoic acid (ATRA), Adapalene or Fenretinide. This led to concentration dependent decrease in the survival fraction in both cell lines with higher efficacy in Cal27 (ED50 ≈ 1 μM) as compared to FaDu cells (ED ≈ 44 μM). Treatment with 3 μM ATRA sensitized Cal27 cells to irradiation at a dose of 2 Gy, but had no or only a minor effect on ALDH1A2-postitive cells.
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1115
Gene URL
https://civic.genome.wustl.edu/links/genes/7024
Variant URL
https://civic.genome.wustl.edu/links/variants/473
Rating
2
Evidence Type
Predictive
Disease
Head And Neck Squamous Cell Carcinoma
Evidence Direction
Supports
Drug
Tretinoin
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
26634247
Drugs
Drug NameSensitivitySupported
TretinoinSensitivitytrue