CI-1040

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Information
Drug Name
CI-1040
Description
Entry(CIViC)
CIViC
[No Data.]
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
CI-1040: MEK inhibitor. Lentiviral vectors were us... BCL2 BCL2 OVEREXPRESSION Resitance or Non-Reponse true MMMP detail
CI-1040: MEK inhibitor. Lentiviral vectors were us... MCL1 MCL1 OVEREXPRESSION Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 P124L Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 I103N Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 L115P Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 F129L Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 UNKNOWN Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor MAP2K1 MAP2K1 Q56P Resitance or Non-Reponse true MMMP detail
This mutation reduces BMF interaction with DLC2, w... BMF BMF A69P Sensitivity true MMMP detail
CI-1040: MEK inhibitor. BMF expression is necessar... BMF BMF UNDEREXPRESSION Resitance or Non-Reponse true MMMP detail
CI-1040 is a MEK inhibitor. Mutation of BRAF is as... BRAF BRAF V600E Sensitivity true MMMP detail
NCT ID Status Phase Summary Start date Completion date
NCT00033384 Completed Phase 2 CI-1040 in Treating Patients With Advanced Breast, Colon, Pancreatic, or Non-Small Cell Lung Cancer February 2002 November 2003
NCT00034827 Completed Phase 2 A Multicenter Phase 2 Study of CI-1040 in Patients With Advanced Nonsmall-Cell Lung, Breast, Colon and Pancreatic Cancer January 2002 May 2003