Annotation Detail
Information
- Associated Genes
- BCL2
- Associated Variants
- BCL2 OVEREXPRESSION
- Source Database
- MMMP
- Description
- CI-1040: MEK inhibitor. Lentiviral vectors were used to deliver and express Bcl-2, Bcl-xL, Bfl-1 and Mcl-1: overexpression of any of these proteins in the sensitive cell line M14-MEL resulted in significant protection from apoptosis induced by CI-1040
- MMMP State
- upregulated by
- MMMP Molecule
- Bcl-2
- MMMP Modifier
- Bcl-2 genetic engineering
- MMMP Relationship
- resistance to
- MMMP Drug
- CI-1040
- MMMP Drug Alias
- PD184352
- MMMP Model
- 3
- MMMP Reference
- VanBrocklin MW, Cancer Res 2009, 69:1985-94
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| CI-1040 | Resitance or Non-Reponse | true |