chr11:92975544:C>G Detail (hg38) (MTNR1B)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr11:92,708,710-92,708,710 View the variant detail on this assembly version. |
| hg38 | chr11:92,975,544-92,975,544 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
| RefSeq | NM_005959.3:c.223+5596C>G | |
| Ensemble | ENST00000257068.3:c.223+5596C>G |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
| JP | HGVD:[No Data.] |
| ToMMo:0.416 | |
| NCBN:[No Data.] | |
| NCBN(Hondo):[No Data.] | |
| NCBN(Ryukyu):[No Data.] | |
| East asia | ExAC:[No Data.] |
Prediction
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.083 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.393 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.466 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.614 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.214 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.336 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.314 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.452 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.296 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.003 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.090 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.341 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.181 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.057 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.017 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.032 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.176 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.293 | Diabetes Mellitus, Non-Insulin-Dependent | To examine the association of type 2 diabetes susceptibility loci and visceral f... | BeFree | 22377712 | Detail |
| 0.123 | polycystic ovary syndrome | Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B)... | BeFree | 20959387 | Detail |
| 0.024 | gestational diabetes | rs10830963 was associated cross-sectionally with fasting glucose (p = 0.0069), a... | BeFree | 24728128 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | Genome-wide trans-ancestry meta-analysis provides insight into the genetic archi... | GWASCAT | 24509480 | Detail |
| 0.124 | obesity | Identified genome-wide significant loci: 1) corroborated genes implicated in oth... | GWASCAT | 23251661 | Detail |
| 0.336 | Diabetes Mellitus, Non-Insulin-Dependent | Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Fi... | BeFree | 24906951 | Detail |
| <0.001 | Sleep Disorders | No effect by the common gene variant rs10830963 of the melatonin receptor 1B on ... | BeFree | 21380592 | Detail |
| 0.005 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| <0.001 | Overweight | Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963... | BeFree | 21366812 | Detail |
| 0.007 | Insulin resistance | [A common variant in MTNR1B was associated with fasting glucose, HbA1C and HOMA-... | GAD | 20398260 | Detail |
| <0.001 | Sleep disturbances | No effect by the common gene variant rs10830963 of the melatonin receptor 1B on ... | BeFree | 21380592 | Detail |
| 0.024 | gestational diabetes | We also found that the risk alleles of rs2383208 (b = -0.085, p = 0.003), rs4402... | BeFree | 22096510 | Detail |
| 0.123 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| 0.214 | Diabetes Mellitus, Non-Insulin-Dependent | Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Fi... | BeFree | 24906951 | Detail |
| 0.002 | Impaired glucose tolerance | The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a st... | BeFree | 19324940 | Detail |
| 0.002 | gestational diabetes | The rs10830963 variant of melatonin receptor MTNR1B is associated with increased... | BeFree | 22450346 | Detail |
| 0.014 | gestational diabetes | Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTN... | BeFree | 23456907 | Detail |
| 0.002 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | MTNR1B rs10830963 was genotyped in a population-based cohort including 3,210 unr... | BeFree | 20398260 | Detail |
| 0.009 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| 0.124 | obesity | The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were geno... | BeFree | 24335056 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTN... | BeFree | 23456907 | Detail |
| 0.614 | Diabetes Mellitus, Non-Insulin-Dependent | Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTN... | BeFree | 23456907 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | An association of the MTNR1B variant rs10830963 with T2D risk was not detected i... | BeFree | 24710643 | Detail |
| <0.001 | Ovarian Diseases | The present study suggest that the SNP, rs10830963, in the MTNR1B gene is not on... | BeFree | 20959387 | Detail |
| 0.162 | Diabetes Mellitus, Non-Insulin-Dependent | Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTN... | BeFree | 23456907 | Detail |
| 0.005 | obesity | Most notably, 5 SNPs from 5 genes [body mass index (BMI), hip circumference: rs3... | BeFree | 25060389 | Detail |
| <0.001 | Overweight | The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were geno... | BeFree | 24335056 | Detail |
| 0.126 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | No effect by the common gene variant rs10830963 of the melatonin receptor 1B on ... | BeFree | 21380592 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | The G-allele of the single nucleotide polymorphism (SNP) rs10830963 in MTNR1B (m... | BeFree | 21366812 | Detail |
| 0.003 | obesity | To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the path... | BeFree | 25919927 | Detail |
| <0.001 | Impaired glucose tolerance | The rs10830963 G-allele increased the risk of i-IFG (odds ratio [OR] 1.64, P = 5... | BeFree | 19324940 | Detail |
| 0.003 | Impaired glucose tolerance | The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a st... | BeFree | 19324940 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fas... | BeFree | 19324940 | Detail |
| 0.281 | Diabetes Mellitus, Insulin-Dependent | For type 1 diabetes, a strong association was seen for MTNR1B (rs10830963, p = 3... | BeFree | 24906951 | Detail |
| 0.374 | Diabetes Mellitus, Non-Insulin-Dependent | G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fas... | BeFree | 19324940 | Detail |
| 0.008 | obesity | Most notably, 5 SNPs from 5 genes [body mass index (BMI), hip circumference: rs3... | BeFree | 25060389 | Detail |
| 0.145 | gestational diabetes | The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A,... | BeFree | 23690305 | Detail |
| <0.001 | Overweight | The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were geno... | BeFree | 24335056 | Detail |
| 0.003 | obesity | The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were geno... | BeFree | 24335056 | Detail |
| 0.290 | Diabetes Mellitus, Non-Insulin-Dependent | Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Fi... | BeFree | 24906951 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we ... | DisGeNET | Detail |
| Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chin... | DisGeNET | Detail |
| rs10830963 was associated cross-sectionally with fasting glucose (p = 0.0069), acute insulin respons... | DisGeNET | Detail |
| Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 di... | DisGeNET | Detail |
| Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ... | DisGeNET | Detail |
| Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Finns) and MTNR1B (rs1... | DisGeNET | Detail |
| No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association betw... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels ... | DisGeNET | Detail |
| [A common variant in MTNR1B was associated with fasting glucose, HbA1C and HOMA-B but not with sleep... | DisGeNET | Detail |
| No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association betw... | DisGeNET | Detail |
| We also found that the risk alleles of rs2383208 (b = -0.085, p = 0.003), rs4402960 (b = -0.057, p =... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Finns) and MTNR1B (rs1... | DisGeNET | Detail |
| The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a state of i-IFG and not... | DisGeNET | Detail |
| The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestationa... | DisGeNET | Detail |
| Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and G... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| MTNR1B rs10830963 was genotyped in a population-based cohort including 3,210 unrelated Chinese Hans ... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight ... | DisGeNET | Detail |
| Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and G... | DisGeNET | Detail |
| Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and G... | DisGeNET | Detail |
| An association of the MTNR1B variant rs10830963 with T2D risk was not detected in our cohort. | DisGeNET | Detail |
| The present study suggest that the SNP, rs10830963, in the MTNR1B gene is not only associated with s... | DisGeNET | Detail |
| Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and G... | DisGeNET | Detail |
| Most notably, 5 SNPs from 5 genes [body mass index (BMI), hip circumference: rs3751812/FTO; fasting ... | DisGeNET | Detail |
| The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight ... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association betw... | DisGeNET | Detail |
| The G-allele of the single nucleotide polymorphism (SNP) rs10830963 in MTNR1B (melatonin receptor 1B... | DisGeNET | Detail |
| To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired... | DisGeNET | Detail |
| The rs10830963 G-allele increased the risk of i-IFG (odds ratio [OR] 1.64, P = 5.5 x 10(-11)) but no... | DisGeNET | Detail |
| The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a state of i-IFG and not... | DisGeNET | Detail |
| G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and ty... | DisGeNET | Detail |
| For type 1 diabetes, a strong association was seen for MTNR1B (rs10830963, p = 3.2 × 10(-6)) and HNF... | DisGeNET | Detail |
| G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and ty... | DisGeNET | Detail |
| Most notably, 5 SNPs from 5 genes [body mass index (BMI), hip circumference: rs3751812/FTO; fasting ... | DisGeNET | Detail |
| The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K,... | DisGeNET | Detail |
| The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight ... | DisGeNET | Detail |
| The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight ... | DisGeNET | Detail |
| Variants in the KCNQ1 (rs2237895, p = 0.0012), HHEX (rs1111875, p = 0.0024 in Finns) and MTNR1B (rs1... | DisGeNET | Detail |
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs10830963 dbSNP
- Genome
- hg38
- Position
- chr11:92,975,544-92,975,544
- Variant Type
- snv
- Reference Allele
- C
- Alternative Allele
- G
- ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- PASS
- Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- rs10830963
- Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 0.4157
- Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 6966
- Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 16758
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