chr17:7668402:> Detail (hg38) (TP53)

Information

Genome

Assembly Position
hg19 chr17:7,571,720-7,590,856 
hg38 chr17:7,668,402-7,687,538

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
lung non-small cell carcinoma Adjuvant Chemotherapy B Predictive Supports Sensitivity/Response N/A 3 26899019 Detail
cancer Nutlin-3a D Predictive Supports Sensitivity/Response N/A 4 17671205 Detail
cancer AMGMDS3 D Predictive Supports Sensitivity/Response N/A 4 25730903 Detail
leukemia RG7112 B Predictive Supports Sensitivity/Response N/A 3 26459177 Detail
colorectal cancer Oxaliplatin,Capecitabine,Cetuximab B Predictive Supports Sensitivity/Response N/A 3 24957073 Detail
esophageal carcinoma Chemotherapy B Predictive Supports Sensitivity/Response N/A 3 23515910 Detail
DisGeNET
[No Data.]
Annotation

Annotations

DescrptionSourceLinks
Pooled analysis of TP53 mutations (exons 5-8) from 4 randomized trials (IALT, JBR10, CALGB-9633 and ... CIViC Evidence Detail
MDM2 Inhibitor Nutlin-3a induced senescence in presence of functional TP53 in murine primary fibrobl... CIViC Evidence Detail
MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows... CIViC Evidence Detail
Phase I Trial of RG7112 in 116 heavily pretreated patients with AML, ALL, CML, CLL, sCLL demonstrate... CIViC Evidence Detail
In this retrospective biomarker analysis of the EXPERT-C trial, patients with TP53 wild-type status ... CIViC Evidence Detail
Patients with p53 wild type (as defined by low expression and/or wild-type tp53 gene) had a higher r... CIViC Evidence Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
Genome
hg38
Position
chr17:7,668,402-7,687,538
Variant Type
snv
Variant (CIViC) (CIViC Variant)
WILD TYPE
Transcript 1 (CIViC Variant)
ENST00000269305.4
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/369
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