chr17:7668402:> Detail (hg38) (TP53)
Information
Genome
Assembly | Position |
---|---|
hg19 | chr17:7,571,720-7,590,856 |
hg38 | chr17:7,668,402-7,687,538 |
HGVS
Type | Transcript | Protein |
---|---|---|
Summary
MGeND
Clinical significance | |
Variant entry | |
GWAS entry | |
Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
Clinical Significance | |
Review star | [No Data.] |
Show details |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
---|---|---|---|---|---|---|---|---|---|
lung non-small cell carcinoma | Adjuvant Chemotherapy | B |
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Sensitivity/Response |
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3 | 26899019 | Detail |
cancer | Nutlin-3a | D |
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Sensitivity/Response |
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4 | 17671205 | Detail |
cancer | AMGMDS3 | D |
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Sensitivity/Response |
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4 | 25730903 | Detail |
leukemia | RG7112 | B |
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Sensitivity/Response |
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3 | 26459177 | Detail |
colorectal cancer | Oxaliplatin,Capecitabine,Cetuximab | B |
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Sensitivity/Response |
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3 | 24957073 | Detail |
esophageal carcinoma | Chemotherapy | B |
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Sensitivity/Response |
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3 | 23515910 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
Descrption | Source | Links |
---|---|---|
Pooled analysis of TP53 mutations (exons 5-8) from 4 randomized trials (IALT, JBR10, CALGB-9633 and ... | CIViC Evidence | Detail |
MDM2 Inhibitor Nutlin-3a induced senescence in presence of functional TP53 in murine primary fibrobl... | CIViC Evidence | Detail |
MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows... | CIViC Evidence | Detail |
Phase I Trial of RG7112 in 116 heavily pretreated patients with AML, ALL, CML, CLL, sCLL demonstrate... | CIViC Evidence | Detail |
In this retrospective biomarker analysis of the EXPERT-C trial, patients with TP53 wild-type status ... | CIViC Evidence | Detail |
Patients with p53 wild type (as defined by low expression and/or wild-type tp53 gene) had a higher r... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
---|
Overlapped Transcript
Gene | Transcript ID | Chromosome | Start | Stop | Links |
---|
- Gene
- -
- Genome
- hg38
- Position
- chr17:7,668,402-7,687,538
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- WILD TYPE
- Transcript 1 (CIViC Variant)
- ENST00000269305.4
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/369
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