Annotation Detail

Information
Associated Genes
TP53
Associated Variants
TP53 WILD TYPE
TP53 WILD TYPE
Associated Disease
esophageal carcinoma
Source Database
CIViC Evidence
Description
Patients with p53 wild type (as defined by low expression and/or wild-type tp53 gene) had a higher response rate to chemotherapy-based treatment (total major response [MR]: risk ratio [RR] = 1.09, 95 % CI = 1.03-1.16, P = .003; pathological MR: RR = 1.15, 95 % CI = 1.06-1.25, P = .001; total complete response [CR]: RR = 1.08, 95 % CI = 1.00-1.17, P = .040) in this meta-analysis (28 studies, 1497 cases).
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/906
Gene URL
https://civic.genome.wustl.edu/links/genes/45
Variant URL
https://civic.genome.wustl.edu/links/variants/369
Rating
3
Evidence Type
Predictive
Disease
Esophageal Carcinoma
Evidence Direction
Supports
Drug
Chemotherapy
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
23515910
Drugs
Drug NameSensitivitySupported
ChemotherapySensitivitytrue