Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 WILD TYPE
TP53 WILD TYPE - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Pooled analysis of TP53 mutations (exons 5-8) from 4 randomized trials (IALT, JBR10, CALGB-9633 and ANITA, 1209 patients, median follow-up 5.5 years) of platinum-based adjuvant chemotherapy (ACT) versus observation (OBS). Patients with wild-type TP53 had better outcomes with ACT than OBS (HROS=0.77 [0.62-0.95], p=0.02; HRDFS=0.75 [0.62-0.92], p=0.005).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1149
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/369
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Adjuvant Chemotherapy
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26899019
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Adjuvant Chemotherapy | Sensitivity | true |