Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 WILD TYPE
TP53 WILD TYPE - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows that only cancer cell lines with unaltered TP53 may be sensitive to MDM2 Inhibitor.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2964
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/369
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- AMGMDS3
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25730903
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AMGMDS3 | Sensitivity | true |