| MDM2 Inhibitor screen in a panel of 260 cancer cel... |
TP53
|
TP53 WILD TYPE
TP53 WILD TYPE
|
Sensitivity |
true |
CIViC Evidence |
detail |
| MDM2 Inhibitor screen in a panel of 260 cancer cel... |
TP53
|
TP53 DELETERIOUS MUTATION
TP53 DELETERIOUS MUTATION
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg248Gln (p.R248Q)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg248Gln (p.R248Q)
(
ENST00000604348.6,
ENST00000504937.5,
ENST00000269305.9,
ENST00000576024.2,
ENST00000420246.6,
ENST00000510385.5,
ENST00000504290.5,
ENST00000610538.4,
ENST00000445888.6,
ENST00000455263.6,
ENST00000359597.8,
ENST00000413465.6,
ENST00000610292.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg248Trp (p.R248W)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg248Trp (p.R248W)
(
ENST00000576024.2,
ENST00000510385.5,
ENST00000269305.9,
ENST00000604348.6,
ENST00000504937.5,
ENST00000359597.8,
ENST00000714409.1,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg175His (p.R175H)
(
ENST00000510385.5,
ENST00000504937.5,
ENST00000604348.6,
ENST00000576024.2,
ENST00000445888.6,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000455263.6,
ENST00000420246.6,
ENST00000504290.5,
ENST00000714357.1,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg175His (p.R175H)
(
ENST00000359597.8,
ENST00000269305.9,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg273Cys (p.R273C)
(
ENST00000576024.2,
ENST00000510385.5,
ENST00000504937.5,
ENST00000604348.6,
ENST00000269305.9,
ENST00000359597.8,
ENST00000420246.6,
ENST00000445888.6,
ENST00000413465.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg273Cys (p.R273C)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg273His (p.R273H)
(
ENST00000445888.6,
ENST00000455263.6,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg273His (p.R273H)
(
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000714357.1,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000714359.1,
ENST00000610292.4,
ENST00000610538.4,
ENST00000714409.1,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000714408.1,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Gly245Ser (p.G245S)
(
ENST00000504937.5,
ENST00000576024.2,
ENST00000510385.5,
ENST00000604348.6,
ENST00000714357.1,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Gly245Ser (p.G245S)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Tyr220Cys (p.Y220C)
(
ENST00000510385.5,
ENST00000504937.5,
ENST00000604348.6,
ENST00000576024.2,
ENST00000504290.5,
ENST00000269305.9,
ENST00000359597.8,
ENST00000618944.4,
ENST00000619186.4,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Tyr220Cys (p.Y220C)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Met237Ile (p.M237I)
(
ENST00000504937.5,
ENST00000510385.5,
ENST00000604348.6,
ENST00000576024.2,
ENST00000455263.6,
ENST00000504290.5,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000714409.1 )
TP53 p.Met237Ile (p.M237I)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg158His (p.R158H)
(
ENST00000604348.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000413465.6,
ENST00000269305.9,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000714409.1,
ENST00000359597.8,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1 )
TP53 p.Arg158His (p.R158H)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Val157Phe (p.V157F)
(
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Val157Phe (p.V157F)
(
ENST00000576024.2,
ENST00000604348.6,
ENST00000510385.5,
ENST00000445888.6,
ENST00000504937.5,
ENST00000455263.6,
ENST00000269305.9,
ENST00000359597.8,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1,
ENST00000413465.6,
ENST00000420246.6,
ENST00000504290.5,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 R249S
TP53 R249S
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 R280K
TP53 R280K
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 R280K
TP53 R280K
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
| Subset of 58 cancer cell lines with unaltered TP53... |
TP53
|
TP53 p.Arg158Leu (p.R158L)
(
ENST00000604348.6,
ENST00000504937.5,
ENST00000510385.5,
ENST00000504290.5,
ENST00000445888.6,
ENST00000455263.6,
ENST00000269305.9,
ENST00000413465.6,
ENST00000576024.2,
ENST00000420246.6,
ENST00000359597.8,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg158Leu (p.R158L)
(
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000504937.5,
ENST00000510385.5,
ENST00000576024.2,
ENST00000604348.6,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4 )
|
Resitance or Non-Reponse |
true |
CIViC Evidence |
detail |
