Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 p.Met237Ile (p.M237I)
(
ENST00000504937.5,
ENST00000510385.5,
ENST00000604348.6,
ENST00000576024.2,
ENST00000455263.6,
ENST00000504290.5,
ENST00000269305.9,
ENST00000359597.8,
ENST00000413465.6,
ENST00000420246.6,
ENST00000445888.6,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000714409.1 )
TP53 p.Met237Ile (p.M237I) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- Subset of 58 cancer cell lines with unaltered TP53 is sensitive to MDM2 Inhibitor AMGMDS3. None of 115 cancer cell lines with TP53 mutation and absence of WT allele are sensitive to MDM2 Inhibitor. TP53 M237I loss of function mutation is present in 1 cell line and it is insensitive to MDM2 Inhibitor AMGMDS3.
- Variant Origin
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/4885
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1066
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- AMGMDS3
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25730903
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AMGMDS3 | Resitance or Non-Reponse | true |