chr11:32396257:> Detail (hg38) (WT1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr11:32,417,803-32,417,953 |
| hg38 | chr11:32,396,257-32,396,407 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| acute myeloid leukemia | Cytarabine,Daunorubicin | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 18591546 | Detail |
| acute myeloid leukemia | B |
Prognostic
|
Does Not Support
|
N/A | Somatic | 3 | 19221039 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Does Not Support
|
N/A | Somatic | 4 | 19221039 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 2 | 19536888 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 2 | 19536888 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 19221039 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 18559874 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 18591546 | Detail | |
| acute myeloid leukemia | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 18591546 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| WT1 mutations were associated with an inferior response to induction chemotherapy with a higher rate... | CIViC Evidence | Detail |
| No differences in relapse-free or overall survival were identified between young (16-60) patients wi... | CIViC Evidence | Detail |
| Rates of complete remission and refractory disease are not different in patients with WT1 mutations ... | CIViC Evidence | Detail |
| Mutations in WT1 were associated with increased risk of recurrence in young patients (15-50) with c... | CIViC Evidence | Detail |
| Mutations in WT1 were associated with a worse overall prognosis than patients wildtype for WT1 in yo... | CIViC Evidence | Detail |
| Patients with WT1 (69% exon 7, 15% exon 9) and FLT3-ITD mutations had significantly lower complete r... | CIViC Evidence | Detail |
| WT mutations were associated with shorter overall and disease free survival in a cohort of cytogenet... | CIViC Evidence | Detail |
| WT1 mutations were a negative prognostic factor for overall survival in young (15-60+, median 45) pa... | CIViC Evidence | Detail |
| WT1 mutations were associated with a higher cumulative incidence of relapse and shorter relapse free... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr11:32,396,257-32,396,407
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXON 7 MUTATION
- Transcript 1 (CIViC Variant)
- ENST00000332351.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/129
- Summary (CIViC Variant)
- WT1 exon 7 mutations have been shown to be recurrent in acute myeloid leukemia. Many sources have examined the prognostic impact of these, agreeing that the mutant exon 7 cohort is correlated with worse overall survival and a number of poor prognistic outcomes. This may be the result of an overall poor response to chemotherapy from WT1 mutant tumors.
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