Annotation Detail
Information
- Associated Genes
- WT1
- Associated Variants
-
WT1 EXON 7 MUTATION
WT1 EXON 7 MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- WT1 mutations were associated with an inferior response to induction chemotherapy with a higher rate of resistant disease in young (15-60+, median 45) patients with cytogenetically normal AML.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/139
- Gene URL
- https://civic.genome.wustl.edu/links/genes/49
- Variant URL
- https://civic.genome.wustl.edu/links/variants/129
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Cytarabine,Daunorubicin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 18591546
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cytarabine | Resitance or Non-Reponse | true |
| Daunorubicin | Resitance or Non-Reponse | true |