Annotation Detail
Information
- Associated Genes
- WT1
- Associated Variants
-
WT1 EXON 7 MUTATION
WT1 EXON 7 MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Mutations in WT1 were associated with a worse overall prognosis than patients wildtype for WT1 in young patients (15-50), primarily because of increased risk of disease recurrence.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/202
- Gene URL
- https://civic.genome.wustl.edu/links/genes/49
- Variant URL
- https://civic.genome.wustl.edu/links/variants/129
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 19536888
Drugs