chr10:87863113:> Detail (hg38) (PTEN)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr10:89,622,870-89,731,687 |
| hg38 | chr10:87,863,113-87,971,930 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| glioblastoma | Gefitinib,Erlotinib | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 16282176 | Detail |
| Her2-receptor positive breast cancer | Fulvestrant,Everolimus | C |
Predictive
|
Supports
|
Resistance | 1 | 27445490 | Detail | |
| glioblastoma | Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 16282176 | Detail |
| glioblastoma | Dacomitinib | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 25939761 | Detail |
| breast cancer | Trastuzumab | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 16404430 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Expression of EGFRvIII and PTEN was evaluated in 26 patients with glioblastomas treated with erlotin... | CIViC Evidence | Detail |
| Case report of a 44-year-old patient with recurrent HER2-positive breast cancer. The primary tumor w... | CIViC Evidence | Detail |
| 49 patients (26 pretreatment tissues available for analysis) with recurrent glioblastomas who were t... | CIViC Evidence | Detail |
| In this preclinical study, the EGFR inhibitor dacomitinib had an effect on cell viability, self-rene... | CIViC Evidence | Detail |
| Trastuzumab was more effective in cell lines (SKBR3 vs. drug-resistant SKBR3/R) and 17 patient sampl... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr10:87,863,113-87,971,930
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000371953.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/313
Genome browser