Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN EXPRESSION
PTEN EXPRESSION - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- In this preclinical study, the EGFR inhibitor dacomitinib had an effect on cell viability, self-renewal and proliferation in EGFR amplified GBM cells in-vitro and in-vivo (with or without the EGFRvIII mutation). It was less effective in one cell-line with PTEN deletion.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/775
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/313
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Drug
- Dacomitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25939761
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacomitinib | Sensitivity | true |