Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN EXPRESSION
PTEN EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- Trastuzumab was more effective in cell lines (SKBR3 vs. drug-resistant SKBR3/R) and 17 patient samples that exhibit elevated PTEN expression (by IHC).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/955
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/313
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Trastuzumab
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 16404430
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Trastuzumab | Sensitivity | true |