Asparaginase
Information
- Drug Name
- Asparaginase
- Description
- Entry(CIViC)
- 9
CIViC
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Lentiviral-mediated overexpression of PRPS1 L191F ... | PRPS1 | PRPS1 L191F PRPS1 L191F | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 S103T ... | PRPS1 | PRPS1 S103I PRPS1 S103I | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 S103N ... | PRPS1 | PRPS1 S103I PRPS1 S103I | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 K176N ... | PRPS1 | PRPS1 K176N PRPS1 K176N | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 D183E ... | PRPS1 | PRPS1 D183E PRPS1 D183E | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 A190T ... | PRPS1 | PRPS1 A190V PRPS1 A190V | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 T303S ... | PRPS1 | PRPS1 T303S PRPS1 T303S | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 N144S ... | PRPS1 | PRPS1 N144S PRPS1 N144S | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| ASNS amplification and expression was associated w... | ASNS |
ASNS AMPLIFICATION ( ENST00000175506.8 ) ASNS AMPLIFICATION ( ENST00000175506.8 ) |
Resitance or Non-Reponse | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00136435 | Active, not recruiting | Phase 2 | A Study in Adults With Untreated Acute Lymphoblastic Leukemia | June 2002 | July 2024 |
| NCT03817320 | Active, not recruiting | Phase 1/Phase 2 | PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma | February 12, 2019 | June 30, 2025 |
| NCT02521493 | Active, not recruiting | Phase 3 | Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome | December 23, 2015 | June 30, 2024 |
| NCT02101853 | Active, not recruiting | Phase 3 | Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia | December 17, 2014 | September 22, 2024 |
| NCT04293562 | Active, not recruiting | Phase 3 | A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations | July 21, 2020 | September 30, 2027 |
| NCT00557193 | Active, not recruiting | Phase 3 | Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | January 15, 2008 | June 28, 2024 |
| NCT01371981 | Active, not recruiting | Phase 3 | Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia | June 20, 2011 | September 30, 2027 |
| NCT00408005 | Active, not recruiting | Phase 3 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma | January 22, 2007 | March 7, 2025 |
| NCT00002785 | Completed | Phase 2 | Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia | July 1996 | March 2007 |
| NCT00002798 | Completed | Phase 3 | Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome | August 1996 | |
| NCT00002812 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia | September 1996 | |
| NCT00003436 | Completed | Phase 3 | Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia | July 1998 | December 2005 |
| NCT00003593 | Completed | Phase 3 | Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome | June 1999 | April 2012 |
| NCT00003650 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma | February 1997 | November 2013 |
| NCT00003671 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia | December 1998 | February 2009 |
| NCT00003700 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia | January 1999 | January 2010 |
| NCT00003783 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia | March 1999 | March 2007 |
| NCT00004056 | Completed | Phase 1 | Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia | October 1999 | March 2007 |
| NCT00004228 | Completed | Phase 3 | Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma | June 2000 | March 31, 2015 |
| NCT00005603 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia | March 2000 | |
| NCT00015873 | Completed | Phase 3 | Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia | May 1999 | December 2009 |
| NCT00016302 | Completed | N/A | Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2001 | |
| NCT00018954 | Completed | Phase 2 | Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma | October 1992 | October 2002 |
| NCT00022126 | Completed | Phase 2 | Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia | November 2002 | April 2006 |
| NCT00022737 | Completed | Phase 3 | Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia | October 2002 | |
| NCT00028899 | Completed | Phase 1 | Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes | July 2002 | March 2012 |
| NCT00049569 | Completed | N/A | Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia | January 2003 | |
| NCT00061945 | Completed | Phase 1/Phase 2 | Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia | June 2003 | October 2012 |
| NCT00070174 | Completed | Phase 2 | Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy | December 2003 | December 2013 |
| NCT00109837 | Completed | Phase 2 | S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2005 | November 2014 |
| NCT00165178 | Completed | Phase 3 | Treatment of Acute Lymphoblastic Leukemia in Children | September 2000 | May 2011 |
| NCT00198978 | Completed | Phase 4 | German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | January 2003 | June 2014 |
| NCT00198991 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) | April 2003 | June 30, 2013 |
| NCT00199004 | Completed | Phase 4 | Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab | April 2004 | March 2009 |
| NCT00199017 | Completed | Phase 4 | German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults | April 2004 | |
| NCT00199056 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) | October 1999 | December 2005 |
| NCT00199069 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) | April 1993 | May 2001 |
| NCT01156883 | Completed | N/A | Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia | April 2010 | October 31, 2017 |
| NCT00002514 | Completed | Phase 3 | Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission | May 7, 1993 | |
| NCT00002665 | Completed | Phase 2 | SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia | July 1995 | December 2003 |
| NCT00002691 | Completed | Phase 2 | Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma | August 1995 | June 2000 |
| NCT00002700 | Completed | Phase 3 | Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia | August 1995 | |
| NCT00002704 | Completed | Phase 2 | Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia | January 1996 | |
| NCT00002744 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | May 1996 | March 2007 |
| NCT00002756 | Completed | Phase 2 | Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia | June 1996 | March 2012 |
| NCT00372593 | Completed | Phase 3 | Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia | August 2006 | September 30, 2020 |
| NCT00381680 | Completed | Phase 3 | Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia | March 2007 | |
| NCT00400946 | Completed | Phase 3 | Treatment of Acute Lymphoblastic Leukemia in Children | April 2005 | June 2019 |
| NCT00430118 | Completed | Phase 3 | Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia | July 2000 | January 2012 |
| NCT00458848 | Completed | Phase 2 | Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia | October 2004 | March 2014 |
| NCT00494897 | Completed | Phase 4 | PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia | June 1996 | December 2007 |
| NCT00537030 | Completed | N/A | Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia | February 11, 2008 | |
| NCT00613457 | Completed | Phase 3 | Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia | September 2000 | July 2006 |
| NCT00720109 | Completed | Phase 2/Phase 3 | Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | July 14, 2008 | March 31, 2020 |
| NCT00784017 | Completed | Phase 3 | Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia | October 2008 | October 2012 |
| NCT00967057 | Completed | Phase 3 | Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia | October 2002 | December 2011 |
| NCT00002471 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | February 1990 | January 2003 |
| NCT01230983 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma | June 1996 | October 2004 |
| NCT04187248 | Completed | The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008 | July 1, 2008 | March 1, 2017 | |
| NCT00369317 | Completed | Phase 3 | Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes | March 2007 | December 31, 2021 |
| NCT00275106 | Terminated | Phase 3 | Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma | September 2004 | August 2012 |
| NCT00262925 | Terminated | Phase 2 | Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia | June 2006 | February 2013 |
| NCT03668392 | Terminated | Phase 2 | Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL) | June 25, 2020 | December 31, 2021 |
| NCT00002532 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia | January 1993 | |
| NCT00764907 | Unknown status | Phase 3 | Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia | November 2002 | |
| NCT00003728 | Unknown status | Phase 3 | Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma | December 1998 | |
| NCT00343369 | Unknown status | N/A | Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia | January 2003 | |
| NCT00003423 | Unknown status | Phase 3 | Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma | May 1995 | |
| NCT00003437 | Unknown status | Phase 3 | Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia | January 1997 | |
| NCT00550992 | Unknown status | N/A | Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia | January 2006 | |
| NCT00002531 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia | January 1993 | |
| NCT00002499 | Unknown status | Phase 2/Phase 3 | Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia | January 1990 | |
| NCT00019409 | Withdrawn | Phase 3 | Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia | October 1999 | July 2001 |
| NCT02538926 | Withdrawn | Phase 2 | Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | July 1, 2018 | July 30, 2021 |