Annotation Detail
Information
- Associated Genes
- ASNS
- Associated Variants
-
ASNS AMPLIFICATION
(
ENST00000175506.8 )
ASNS AMPLIFICATION ( ENST00000175506.8 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- ASNS amplification and expression was associated with resistance to L-asparaginase in ovarian cancer and leukemia cell lines. ASNS silencing increased sensitivity to l-ASP in 2/3 of ovarian cancer cell lines.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/953
- Gene URL
- https://civic.genome.wustl.edu/links/genes/446
- Variant URL
- https://civic.genome.wustl.edu/links/variants/409
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Asparaginase
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 17088436
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Asparaginase | Resitance or Non-Reponse | true |