Annotation Detail

Information

Associated Genes: PRPS1
Associated Variants: PRPS1 S103I
PRPS1 S103I
Associated Disease: childhood B-cell acute lymphoblastic leukemia
Source Database: CIViC Evidence
Description: Lentiviral-mediated overexpression of PRPS1 S103T in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS1 overexpression controls as indicated similar cytotoxicity curves and IC50s.
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/7924
Gene URL: https://civic.genome.wustl.edu/links/genes/4566
Variant URL: https://civic.genome.wustl.edu/links/variants/2927
Rating: 3
Evidence Type: Predictive
Disease: Childhood B-cell Acute Lymphoblastic Leukemia
Evidence Direction: Does Not Support
Drug: Methotrexate,Cytarabine,Daunorubicin,Asparaginase
Evidence Level: D
Clinical Significance: Resistance
Pubmed: 25962120

Drugs