Annotation Detail
Information
- Associated Genes
- RORA
- Associated Variants
-
CRY2 c.215+921A>G
(
ENST00000616623.4,
ENST00000616080.2,
ENST00000443527.6,
ENST00000417225.6 )
rs2287161
RORA c.295+7777T>C ( ENST00000261523.9, ENST00000449337.6, ENST00000335670.11, ENST00000309157.8 )
NR1D1 c.370+106G>A ( ENST00000246672.4 )
NPAS2 p.Ser471Leu (p.S471L) ( ENST00000335681.10 )
RORB c.41-6338T>C ( ENST00000376896.8, ENST00000396204.2 )
RORB c.41-745G>A ( ENST00000376896.8, ENST00000396204.2 )
RORB c.127-165C>T ( ENST00000376896.8, ENST00000396204.2 )
RORB c.670+6497T>A ( ENST00000376896.8, ENST00000396204.2 )
CRY2 c.215+921A>G ( ENST00000417225.6, ENST00000443527.6, ENST00000616080.2, ENST00000616623.4 )
rs2287161
RORA c.295+7777T>C ( ENST00000261523.9, ENST00000309157.8, ENST00000335670.11, ENST00000449337.6 )
NR1D1 c.370+106G>A ( ENST00000246672.4 )
NPAS2 p.Ser471Leu (p.S471L) ( ENST00000335681.10 )
RORB c.41-6338T>C ( ENST00000376896.8, ENST00000396204.2 )
RORB c.41-745G>A ( ENST00000376896.8, ENST00000396204.2 )
RORB c.127-165C>T ( ENST00000376896.8, ENST00000396204.2 )
RORB c.670+6497T>A ( ENST00000376896.8, ENST00000396204.2 ) - Associated Disease
- bipolar disorder
- Source Database
- DisGeNET
- Description
- The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
- Pubmed
- 22538398
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00581983144552528
- Year of publication
- 2012
Drugs