Annotation Detail
Information
- Associated Genes
- PTPA
- Associated Variants
-
PTPA MUTATION
PTPA MUTATION - Associated Disease
- Adenocarcinoma of pancreas
- Source Database
- DisGeNET
- Description
- Methylation of MAP3K2 prevents it from binding to the phosphatase PP2A, thereby impeding the impact of this negative regulator on Ras-ERK1/2 signals, leading to the formation of lung and pancreatic adenocarcinomas.
- Pubmed
- 25382779
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs