PI3Kbeta Inhibitor AZD8186
Information
- Drug Name
- PI3Kbeta Inhibitor AZD8186
- Description
- Entry(CIViC)
- 3
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| pancreatic adenocarcinoma | KRAS MUTATION KRAS MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 26725216 | Detail |
| prostate cancer | PTEN MUTATION PTEN MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 25544636 | Detail |
| breast cancer |
PTEN DELETION ( ENST00000371953.8 ) PTEN DELETION ( ENST00000371953.8 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 25398829 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Inhibition of ERK in 11 KRAS mutant pancreatic can... | KRAS | KRAS MUTATION KRAS MUTATION | Sensitivity | true | CIViC Evidence | detail |
| Castrated mice bearing androgen-sensitive human pr... | PTEN | PTEN MUTATION PTEN MUTATION | Sensitivity | true | CIViC Evidence | detail |
| Breast and prostate cancer cell lines responsive t... | PTEN |
PTEN DELETION ( ENST00000371953.8 ) PTEN DELETION ( ENST00000371953.8 ) |
Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03218826 | Active, not recruiting | Phase 1 | PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery | September 24, 2018 | September 22, 2024 |