Annotation Detail

Information

Associated Genes: PTEN
Associated Variants: PTEN MUTATION
PTEN MUTATION
Associated Disease: prostate cancer
Source Database: CIViC Evidence
Description: Castrated mice bearing androgen-sensitive human prostate adenocarcinomas (LNCaP tumors) were treated with PI3K inhibitors (AZD8186, BYL719) and an androgen receptor inhibitor (MDV3100). Mice treated with single therapy of either MDV3100, BYL719, or AZD8186 resulted in mild tumor growth inhibition of 90%, 36%, and 40% respectively (n=5 mice/group). However, triple therapy of MDV300, BYL719, and AZD8186 resulted in tumor regression of 113% (n=5 mice).
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/1522
Gene URL: https://civic.genome.wustl.edu/links/genes/41
Variant URL: https://civic.genome.wustl.edu/links/variants/510
Rating: 3
Evidence Type: Predictive
Disease: Prostate Cancer
Evidence Direction: Supports
Drug: Alpelisib,Enzalutamide,PI3Kbeta Inhibitor AZD8186
Evidence Level: D
Clinical Significance: Sensitivity/Response
Pubmed: 25544636

Drugs