Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN DELETION
(
ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- Breast and prostate cancer cell lines responsive to AZD8186 were enriched for PTEN deficiency.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/711
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/214
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- PI3Kbeta Inhibitor AZD8186
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25398829
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PI3Kbeta Inhibitor AZD8186 | Sensitivity | true |