O6-Benzylguanine
Information
- Drug Name
- O6-Benzylguanine
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| glioblastoma | MGMT PROMOTER METHYLATION MGMT PROMOTER METHYLATION | E |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 11070098 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| In patients lacking MGMT promoter methylation, the... | MGMT | MGMT PROMOTER METHYLATION MGMT PROMOTER METHYLATION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00002604 | Completed | Phase 1 | O(6)-Benzylguanine and Carmustine in Treating Patients With Solid Tumors | January 1996 | February 2004 |
| NCT00002971 | Completed | Phase 1 | O(6)-Benzylguanine in Treating Patients With Malignant Glioma | June 19, 1997 | January 1, 2009 |
| NCT00003348 | Completed | Phase 1 | Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain | May 1998 | August 2000 |
| NCT00005961 | Completed | Phase 2 | O6-benzylguanine and Carmustine in Treating Patients With Unresectable Locally Recurrent or Metastatic Melanoma | June 2000 | |
| NCT00005981 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer | June 2000 | November 2003 |
| NCT00006474 | Completed | Phase 1 | Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma | March 2001 | August 2004 |
| NCT00017147 | Completed | Phase 3 | S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma | September 2001 | November 2012 |
| NCT00020150 | Completed | Phase 1 | Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors | June 2000 | |
| NCT00052780 | Completed | Phase 1 | Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors | October 2002 | |
| NCT00253487 | Completed | N/A | Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas | August 2005 | August 2012 |
| NCT00275002 | Completed | Phase 2 | O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors | February 2006 | December 2010 |
| NCT00961220 | Completed | Phase 1/Phase 2 | O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma | February 1, 2010 | April 8, 2014 |
| NCT01269424 | Completed | Phase 1 | BG & TMZ Therapy of Glioblastoma Multiforme | November 22, 2011 | September 26, 2022 |
| NCT00003765 | Completed | Phase 1 | O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors | May 1999 | |
| NCT00003766 | Completed | Phase 1 | O6-benzylguanine Followed by Surgery in Treating Patients With Solid Tumors That Can Be Removed During Surgery | October 1999 | November 2001 |
| NCT00004072 | Completed | Phase 2 | O6-benzylguanine And Carmustine in Treating Patients With Multiple Myeloma | September 1999 | September 2004 |
| NCT00004892 | Completed | Phase 1 | O6-Benzylguanine and Carmustine Implants in Treating Patients With Recurrent Malignant Glioma | April 2000 | |
| NCT00005066 | Completed | Phase 2 | O6-benzylguanine and Carmustine in Treating Patients With Recurrent, Metastatic, or Locally Advanced Soft Tissue Sarcoma | June 2000 | October 2002 |
| NCT00005081 | Completed | Phase 2 | Carmustine Plus O6-benzylguanine in Treating Patients With Recurrent or Progressive Glioma | August 2000 | April 2001 |
| NCT05052957 | Recruiting | Phase 2 | hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) | January 20, 2023 | December 1, 2024 |
| NCT00003613 | Terminated | Phase 1 | O6-benzylguanine and Carmustine in Treating Patients With Stage IA-IIA Cutaneous T-cell Lymphoma | April 1999 | |
| NCT00436436 | Terminated | Phase 2 | O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy | November 13, 2006 | April 14, 2010 |
| NCT00669669 | Terminated | Phase 1/Phase 2 | O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas | February 25, 2009 | January 20, 2021 |
| NCT00003567 | Terminated | Phase 1 | Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma | May 1999 | February 2007 |
| NCT00045721 | Terminated | Phase 1 | Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma | March 2003 | July 2004 |
| NCT00086970 | Terminated | Phase 1 | Ifosfamide With or Without O(6)-Benzylguanine in Treating Patients With Unresectable, Metastatic Solid Tumors | June 2004 | |
| NCT02343666 | Withdrawn | Phase 1 | HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection | August 15, 2016 | |
| NCT01769911 | Withdrawn | N/A | Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma | February 2015 | |
| NCT00046878 | Withdrawn | Phase 2 | Carmustine and O(6)-Benzylguanine in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme | August 2002 |