Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
-
MGMT PROMOTER METHYLATION
MGMT PROMOTER METHYLATION - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- In patients lacking MGMT promoter methylation, the use of an MGMT inhibitor, such as O(6)-benzylguanine, in combination with alkylating agents (Carmustine) may be useful in treating patients with initial resistance to alkylating agents.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/309
- Gene URL
- https://civic.genome.wustl.edu/links/genes/34
- Variant URL
- https://civic.genome.wustl.edu/links/variants/85
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Drug
- O6-Benzylguanine
- Evidence Level
- E
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 11070098
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| O6-Benzylguanine | Sensitivity | true |