Annotation Detail

Information
Associated Genes
MUTYH
Associated Variants
APEX1 p.Asp148Glu (p.D148E) ( ENST00000557054.1, ENST00000398030.8, ENST00000216714.8, ENST00000555414.5 )
APEX1 p.Asp148Glu (p.D148E) ( ENST00000555414.5, ENST00000216714.8, ENST00000557054.1, ENST00000398030.8 )
LIG3 p.Arg867His (p.R867H) ( ENST00000378526.9, ENST00000262327.9 )
XRCC1 p.Gln399Arg (p.Q399R) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg280Pro (p.R280P) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg280His (p.R280H) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg194Trp (p.R194W) ( ENST00000262887.10, ENST00000543982.5 )
PARP1 p.Val762Ala (p.V762A) ( ENST00000366794.10, ENST00000677203.1 )
MUTYH c.-127C>T, TOE1 c.52+77G>A, ENSG00000288208 c.541-5870C>T ( ENST00000372090.6, ENST00000372110.7, ENST00000710952.2, ENST00000529892.6, ENST00000372098.7, ENST00000672818.3, ENST00000372115.7, ENST00000529984.5 )
MUTYH c.-127C>A, TOE1 c.52+77G>T, ENSG00000288208 c.541-5870C>A ( ENST00000710952.2, ENST00000372110.7, ENST00000372090.6, ENST00000672818.3, ENST00000372098.7, ENST00000529892.6, ENST00000529984.5, ENST00000372115.7 )
OGG1 c.948+273C>G ( ENST00000302003.11, ENST00000302008.12, ENST00000302036.12, ENST00000339511.9, ENST00000344629.12, ENST00000352937.6, ENST00000383826.9, ENST00000449570.6, ENST00000707074.1 )
APEX1 p.Asp148Glu (p.D148E) ( ENST00000216714.8, ENST00000398030.8, ENST00000555414.5, ENST00000557054.1 )
APEX1 p.Asp148Glu (p.D148E) ( ENST00000216714.8, ENST00000398030.8, ENST00000555414.5, ENST00000557054.1 )
LIG3 p.Arg867His (p.R867H) ( ENST00000262327.9, ENST00000378526.9 )
XRCC1 p.Gln399Arg (p.Q399R) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg280Pro (p.R280P) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg280His (p.R280H) ( ENST00000262887.10, ENST00000543982.5 )
XRCC1 p.Arg194Trp (p.R194W) ( ENST00000262887.10, ENST00000543982.5 )
PARP1 p.Val762Ala (p.V762A) ( ENST00000366794.10, ENST00000677203.1 )
MUTYH c.-127C>T, TOE1 c.52+77G>A, ENSG00000288208 c.541-5870C>T ( ENST00000372098.7, ENST00000372110.7, ENST00000372115.7, ENST00000529892.6, ENST00000529984.5, ENST00000672818.3, ENST00000710952.2, ENST00000372090.6 )
MUTYH c.-127C>A, TOE1 c.52+77G>T, ENSG00000288208 c.541-5870C>A ( ENST00000372098.7, ENST00000372110.7, ENST00000372115.7, ENST00000529892.6, ENST00000529984.5, ENST00000672818.3, ENST00000710952.2, ENST00000372090.6 )
OGG1 c.948+273C>G ( ENST00000302003.11, ENST00000302008.12, ENST00000302036.12, ENST00000339511.9, ENST00000344629.12, ENST00000352937.6, ENST00000383826.9, ENST00000449570.6, ENST00000707074.1 )
Associated Disease
melanoma
Source Database
DisGeNET
Description
We hypothesized that common nsSNPs of BER genes, specifically ADPRT rs1136410, XRCC1 rs25487, rs25489, rs1799782, APEX1 rs1130409, OGG1 rs1052133, LIG3 rs3136025 and MUTYH rs3219466, may contribute to risk of melanoma.
Pubmed
22687647
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.000542883744160607
Year of publication
2012
Drugs