Annotation Detail
Information
- Associated Genes
- IGF1R
- Associated Variants
-
IGF1R MUTATION
IGF1R MUTATION - Associated Disease
- Advanced cancer
- Source Database
- DisGeNET
- Description
- Our study provides proof-of-concept that inhibiting the IGF1R compensatory response to mTOR inhibition is feasible with promising clinical activity in heavily pretreated advanced cancer, particularly in ER(+)/high-proliferative breast cancer (ClinicalTrials.gov identifier: NCT00730379).
- Pubmed
- 25320355
- Section of the abstract supporting the evidence
- CONCLUSIONS
- Number of the section of the abstract supporting the evidence
- 4
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs