Annotation Detail
Information
- Associated Genes
- PTPA
- Associated Variants
-
PTPA MUTATION
PTPA MUTATION - Associated Disease
- Multiple malignancy
- Source Database
- DisGeNET
- Description
- The oncoprotein Cancerous Inhibitor of PP2A (CIP2A) has been reported to interact with Protein phosphatase 2 (PP2A) to stabilize c-Myc and prevent its degradation, and high expression levels of CIP2A have been proved to be related to poor clinical outcomes in multiple cancers.
- Pubmed
- 25458953
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs