Annotation Detail
Information
- Associated Genes
- LCN2
- Associated Variants
-
LCN2 MUTATION
LCN2 MUTATION - Associated Disease
- intrahepatic cholangiocarcinoma
- Source Database
- DisGeNET
- Description
- The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC.
- Pubmed
- 24939880
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs