Annotation Detail
Information
- Associated Genes
- IRF1
- Associated Variants
-
IRF1 MUTATION
IRF1 MUTATION - Associated Disease
- Skin Neoplasms
- Source Database
- DisGeNET
- Description
- These studies define a novel mechanism associated with skin tumor promotion by the anthrone class of tumor promoters involving upregulation of IFNγ signaling in the epidermis and downstream signaling through activated (phosphorylated) Stat1, IRF-1 and uStat1.
- Pubmed
- 24464587
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs