Annotation Detail
Information
- Associated Genes
- CDX2
- Associated Variants
-
rs16969681
rs16969681 - Associated Disease
- colorectal carcinoma
- Source Database
- DisGeNET
- Description
- The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors.
- Pubmed
- 25131200
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0122148842436137
- Year of publication
- 2014
Drugs