Annotation Detail
Information
- Associated Genes
- TNFSF10
- Associated Variants
-
TNFSF10 MUTATION
TNFSF10 MUTATION - Associated Disease
- colorectal carcinoma
- Source Database
- DisGeNET
- Description
- Moreover, treatment of CRC cells with TRAIL or ABT‑737 induces a release of endogenous HMGB1 into the extracellular space, and preincubation with glycyrrhizin, an HMGB1 inhibitor, significantly inhibits induction of cell death by TRAIL and ABT‑737, suggesting that HMGB1 functionally contributes to the execution of cell death triggered by pro-apoptotic agents.
- Pubmed
- 25434832
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00488595369744546
Drugs