Annotation Detail
Information
- Associated Genes
- IL23R
- Associated Variants
-
IL23R MUTATION
IL23R MUTATION
SLC14A2 p.Leu411Phe (p.L411F) ( ENST00000255226.11, ENST00000586448.5 )
rs6682925 ( ENST00000697222.1, ENST00000371007.6 )
IL5RA c.-37T>C ( ENST00000256452.7, ENST00000311981.12, ENST00000383846.5, ENST00000418488.6, ENST00000430514.6, ENST00000438560.5, ENST00000446632.7, ENST00000456302.5 )
TLR3 p.Leu412Val (p.L412V) ( ENST00000296795.8, ENST00000504367.1, ENST00000508051.2, ENST00000512264.1, ENST00000698351.1, ENST00000698354.1 )
TLR3 p.Leu412Phe (p.L412F) ( ENST00000296795.8, ENST00000504367.1, ENST00000508051.2, ENST00000512264.1, ENST00000698351.1, ENST00000698354.1 )
rs5743551
SLC14A2 p.Leu411Phe (p.L411F) ( ENST00000255226.11, ENST00000586448.5 )
rs6682925 ( ENST00000697222.1, ENST00000371007.6 )
IL5RA c.-37T>C ( ENST00000256452.7, ENST00000311981.12, ENST00000383846.5, ENST00000418488.6, ENST00000430514.6, ENST00000438560.5, ENST00000446632.7, ENST00000456302.5 )
TLR3 p.Leu412Val (p.L412V) ( ENST00000296795.8, ENST00000504367.1, ENST00000508051.2, ENST00000512264.1, ENST00000698351.1, ENST00000698354.1 )
TLR3 p.Leu412Phe (p.L412F) ( ENST00000296795.8, ENST00000504367.1, ENST00000508051.2, ENST00000512264.1, ENST00000698351.1, ENST00000698354.1 )
rs5743551 - Associated Disease
- Non-small cell lung carcinoma
- Source Database
- DisGeNET
- Description
- Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
- Pubmed
- 21412764
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2012
Drugs