Annotation Detail

Information
Associated Genes
PSEN1
Associated Variants
PSEN1 p.Pro267Ser (p.P267S) ( ENST00000357710.8, ENST00000700324.1, ENST00000557511.5, ENST00000700468.1, ENST00000700268.1, ENST00000700437.1, ENST00000554131.6, ENST00000700306.1, ENST00000556951.6, ENST00000700375.1, ENST00000553599.6, ENST00000700312.1, ENST00000700267.1, ENST00000700269.1, ENST00000700322.1, ENST00000324501.10, ENST00000700317.1, ENST00000700321.1, ENST00000700273.1, ENST00000557293.6, ENST00000700313.1, ENST00000700323.1, ENST00000700320.1, ENST00000700271.1, ENST00000700378.1, ENST00000394164.5, ENST00000700265.1, ENST00000700389.1, ENST00000700469.1, ENST00000700307.1 )
PSEN1 p.Pro267Ser (p.P267S) ( ENST00000324501.10, ENST00000357710.8, ENST00000394164.5, ENST00000553599.6, ENST00000554131.6, ENST00000556951.6, ENST00000557293.6, ENST00000557511.5, ENST00000700265.1, ENST00000700267.1, ENST00000700268.1, ENST00000700269.1, ENST00000700271.1, ENST00000700273.1, ENST00000700306.1, ENST00000700307.1, ENST00000700312.1, ENST00000700313.1, ENST00000700317.1, ENST00000700320.1, ENST00000700321.1, ENST00000700322.1, ENST00000700323.1, ENST00000700324.1, ENST00000700375.1, ENST00000700378.1, ENST00000700389.1, ENST00000700437.1, ENST00000700468.1, ENST00000700469.1 )
Associated Disease
not provided
Source Database
ClinVar
Description
NM_000021.4(PSEN1):c.799C>T (p.Pro267Ser) AND not provided
ClinVar Allele ID
33172
ClinVar RefSeq Alternation Syntax
NM_000021.4:c.799C>T
ClinVar RefSeq Alternation Syntax
NM_007318.3:c.787C>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2016-11-02
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000084371
ClinVar Disease
not provided
Observed Origin Sample
germline
Observed Origin Sample
not provided
Drugs