Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
-
MGMT PROMOTER METHYLATION
MGMT PROMOTER METHYLATION - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- MGMT promoter methylation has been shown to confer sensitivity to alkylating agents, such as carmustine, in glioblastoma cells.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/308
- Gene URL
- https://civic.genome.wustl.edu/links/genes/34
- Variant URL
- https://civic.genome.wustl.edu/links/variants/85
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Drug
- Carmustine
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 11070098
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Carmustine | Sensitivity | true |