Annotation Detail

Information
Associated Genes
MGMT
Associated Variants
MGMT UNDEREXPRESSION ( ENST00000306010.8 )
MGMT UNDEREXPRESSION ( ENST00000306010.8 )
Associated Disease
oligodendroglioma
Source Database
CIViC Evidence
Description
In this study, loss of chromosome 1p and low MGMT protein expression were associated with objective response (P < .003 and P < .04, respectively). However, only 54% of the study group had evaluation of 1p/19q status, and MGMT protein expression was studied in only 33%. Therefore, the association between 1p deletion and low MGMT protein expression was statistically significant when evaluated further and verified in the extended group of 31 patients with low-grade oligodendrogliomas.
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/2902
Gene URL
https://civic.genome.wustl.edu/links/genes/34
Variant URL
https://civic.genome.wustl.edu/links/variants/1255
Rating
2
Evidence Type
Predictive
Disease
Oligodendroglioma
Evidence Direction
Supports
Drug
Temozolomide
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
16541434
Drugs
Drug NameSensitivitySupported
TemozolomideSensitivitytrue