Annotation Detail
Information
- Associated Genes
- BAP1
- Associated Variants
-
BAP1 MUTATION
BAP1 MUTATION - Associated Disease
- malignant mesothelioma
- Source Database
- CIViC Evidence
- Description
- A siRNA screen identified BAP1 associated with HDAC1 and HDAC2 expression. HDAC2 or BAP1 depletion sensitized a mesothelioma cell line (MSTO-211H) to HDAC inhibitors MC1568, vorinostat or mocetinostat. The paper indicates however, that temporary BAP knockdown might not adequately reflect long-term BAP1 mutation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1235
- Gene URL
- https://civic.genome.wustl.edu/links/genes/70
- Variant URL
- https://civic.genome.wustl.edu/links/variants/183
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Malignant Mesothelioma
- Evidence Direction
- Supports
- Drug
- Vorinostat,Mocetinostat,MC1568
- Evidence Level
- E
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25970771
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| MC1568 | Sensitivity | true |
| Mocetinostat | Sensitivity | true |
| Vorinostat | Sensitivity | true |