PLX4720

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Information
Drug Name
PLX4720
Description
Entry(CIViC)
3
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
skin melanoma GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) 		D Predictive Supports Resistance Somatic 3 24504448 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		D Predictive Supports Sensitivity/Response Somatic 3 23845441 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		D Predictive Supports Sensitivity/Response Somatic 2 23812671 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
Cells were derived from a 26-year old patient with... GNAQ GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) 		Resitance or Non-Reponse true CIViC Evidence detail
Combined PI3K inhibitor GDC0941 and BRAF inhibitor... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		Sensitivity true CIViC Evidence detail
Combined nutlin-3 and PLX4720 administration to at... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		Sensitivity true CIViC Evidence detail