Enzastaurin

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Information
Drug Name
Enzastaurin
Description
Entry(CIViC)
1
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
lung non-small cell carcinoma JAK1 OVEREXPRESSION
( ENST00000342505.5 ) JAK1 OVEREXPRESSION
( ENST00000342505.5 ) 		D Predictive Supports Sensitivity/Response N/A 4 22333600 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
Overexpression of JAK1 in 22 lung cancer cell line... JAK1 JAK1 OVEREXPRESSION
( ENST00000342505.5 ) JAK1 OVEREXPRESSION
( ENST00000342505.5 ) 		Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT00088205 Completed Phase 2 Oral Enzastaurin in Participants With Relapsed Mantle Cell Lymphoma March 2004 May 2008
NCT00190723 Completed Phase 2 A Study of LY317615 in Patients With Brain Tumors October 2002 December 2006
NCT00267020 Completed Phase 2 Phase 2 Study of Gemcitabine or Gemcitabine + Enzastaurin in Participants With Advanced or Metastatic Pancreatic Cancer December 2005 May 2008
NCT00295815 Completed Phase 3 Enzastaurin Versus Lomustine in Glioblastoma January 2006 May 2014
NCT00308750 Completed Phase 2 First Line Chemotherapy Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) March 2006 July 2009
NCT00309140 Completed Phase 2 An Open Label Study of Oral Enzastaurin in Participants With Cancer March 2006 July 2009
NCT00332202 Completed Phase 3 PRELUDE:Study to Investigate the Prevention of Relapse in Lymphoma Using Daily Enzastaurin June 2006 July 2013
NCT00391118 Completed Phase 2 Comparing Two Treatments for Ovarian Cancer: Standard Chemotherapy Plus Enzastaurin, or Placebo ("Sugar Pill") November 2006 July 2012
NCT00402116 Completed Phase 1/Phase 2 Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients September 2006 December 2009
NCT00414960 Completed Phase 2 A Trial of Placebo Versus Enzastaurin for Lung Cancer Prevention in Former Smokers December 2007 September 2010
NCT00415363 Completed Phase 2 Study of Enzastaurin Versus Placebo in the Treatment of Patients With Brain Metastases of Lung Cancer, After Whole Brain Radiation Therapy December 2006 January 2011
NCT00420381 Completed Phase 2 Evaluation of Enzastaurin in the Treatment of Persistent or Recurrent Ovarian or Primary Peritoneal Cancer January 2007 December 2014
NCT00428714 Completed Phase 2 Phase 2 Trial of Enzastaurin in Prostate Cancer in Participants Who Have Had Hormonal and Chemotherapy January 2007 January 2011
NCT00436280 Completed Phase 2 Chemotherapy for Participants With Lymphoma February 2007 November 2012
NCT00437268 Completed Phase 2 A Study of Irinotecan Plus Cetuximab With or Without Enzastaurin in Participants With Colorectal Cancer March 2007 May 2009
NCT00718419 Completed Phase 2 A Study for Patients That Have Been Previously Been Treated in Waldenstrom's Macroglobulinemia or Multiple Myeloma July 2008 August 2012
NCT00744991 Completed Phase 2 A Study for Participants With Relapsed Cutaneous T-Cell Lymphoma September 2008 February 2010
NCT01388335 Completed Phase 1 A Drug Interaction Study to Assess the Effect of LY317615 on the Metabolic Pathway of Warfarin August 2011 December 2012
NCT01432951 Completed Phase 1 A Study of Enzastaurin in Chinese Patients With Advanced and/or Metastatic Solid Tumors or Lymphoma November 2011 January 5, 2018
NCT00451178 Completed Phase 2 A Study of Participants With Lymphoma Who Take R-CHOP and Enzastaurin Compared to Participants Who Take R-CHOP Only May 2007 January 2013
NCT00451555 Completed Phase 2 Enzastaurin Plus Fulvestrant vs. Placebo Plus Fulvestrant in Breast Cancer April 11, 2007 October 18, 2018
NCT00452257 Completed Phase 1 A Study of Enzastaurin in Patients With Leukemia May 2007 September 2008
NCT00452413 Completed Phase 1/Phase 2 A Study of Enzastaurin and Erlotinib in Participants With Solid Tumors and Lung Cancer May 2007 November 2013
NCT00466440 Completed Phase 2 A Phase 2 Study With Enzastaurin Plus Chemotherapy or Placebo Plus Chemotherapy for Prostate Cancer Patients June 2007 June 2010
NCT00475644 Completed Phase 2 A Study of Enzastaurin in Participants With Follicular Lymphoma May 2007 December 2014
NCT00530621 Completed Phase 2 Study of Enzastaurin Versus Placebo With Pemetrexed for Participants With Advanced or Metastatic Lung Cancer September 2007 October 2008
NCT00533429 Completed Phase 2 Study of Pemetrexed + Carboplatin + Bevacizumab + Enzastaurin Versus Pemetrexed + Carboplatin + Bevacizumab + Placebo in Participants With Non-Small Cell Lung Cancer Who Have Not Been Previously Treated With Chemotherapy October 2007 February 2009
NCT00542919 Completed Phase 2 A Study for Patients With Non-Hodgkin's Lymphomas November 2007 February 27, 2018
NCT00586508 Completed Phase 2 Trial of Enzastaurin and Bevacizumab in Participants With Recurrent Malignant Gliomas November 2007 October 2013
NCT00612586 Completed Phase 2 Study of Enzastaurin With 5-Fluorouracil/Leucovorin (5-FU/LV) Plus Bevacizumab as Maintenance Regimen Following First Line Therapy for Metastatic Colon Cancer February 2008 November 2011
NCT00709995 Completed Phase 2 A Study for Participants With Metastatic Renal Cell Carcinoma June 30, 2008 September 5, 2018
NCT05463679 Suspended Phase 3 Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome. January 2025 March 2027
NCT00437294 Terminated Phase 2 Enzastaurin in Combination of Capecitabine to Treat Breast Cancer March 2007 March 2009
NCT00538681 Terminated Phase 2 Study for Participants With Advanced, Not Amenable to Surgery, or Metastatic Lung Cancer Comparing Treatment With Pemetrexed + Cisplatin + Enzastaurin Versus Pemetrexed + Cisplatin + Placebo September 2007 November 2008
NCT00536939 Terminated Phase 2 Trial of Paclitaxel, Bevacizumab, and Enzastaurin Versus Paclitaxel, Bevacizumab and Placebo for Breast Cancer November 2007 March 2008