Annotation Detail

Information
Associated Genes
JAK1
Associated Variants
JAK1 OVEREXPRESSION ( ENST00000342505.5 )
JAK1 OVEREXPRESSION ( ENST00000342505.5 )
Associated Disease
lung non-small cell carcinoma
Source Database
CIViC Evidence
Description
Overexpression of JAK1 in 22 lung cancer cell lines was associated with sensitivity to PKC-inhibitor enzastaurin. Silencing of JAK1 (by small molecule JAK 1/2/3 inhibitor) led to resistance. Overexpression of JAK1 (lentiviral mediated) led to sensitivity to enzastaurin.
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/931
Gene URL
https://civic.genome.wustl.edu/links/genes/3090
Variant URL
https://civic.genome.wustl.edu/links/variants/396
Rating
4
Evidence Type
Predictive
Disease
Lung Non-small Cell Carcinoma
Evidence Direction
Supports
Drug
Enzastaurin
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
22333600
Drugs
Drug NameSensitivitySupported
EnzastaurinSensitivitytrue