Cytoreductive Surgery
Information
- Drug Name
- Cytoreductive Surgery
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| peritoneal mesothelioma | EGFR MUTATION EGFR MUTATION | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 20942962 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| 25 patients with metastatic peritoneal mesotheliom... | EGFR | EGFR MUTATION EGFR MUTATION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01815359 | Active, not recruiting | Phase 2 | ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis | March 2013 | September 2026 |
| NCT03245892 | Active, not recruiting | Phase 1 | A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab With or Without Ipilimumab in Patients With Ovarian Cancer | August 4, 2017 | August 2025 |
| NCT00625092 | Completed | Phase 1 | Hyperthermic Intraperitoneal Oxaliplatin for Peritoneal Malignancies | October 2007 | September 2011 |
| NCT00820157 | Completed | N/A | Cytoreductive Surgery and Transarterial Chemoembolization (TACE) Versus TACE for Hepatocellular Carcinoma | November 2008 | December 2012 |
| NCT01257594 | Completed | Phase 1 | EGFR Inhibition Using Weekly Erlotinib for Recurrent Malignant Gliomas | January 7, 2011 | December 31, 2018 |
| NCT00052962 | Completed | Phase 3 | Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis | January 2003 | September 2008 |
| NCT01833832 | Completed | Phase 2 | Surgery and Heated Chemotherapy for Adrenocortical Carcinoma | April 12, 2013 | August 9, 2018 |
| NCT02238496 | Completed | Phase 1 | Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas | December 8, 2014 | February 14, 2021 |
| NCT02399410 | Completed | Phase 2 | Perioperative Chemotherapy With Bevacizumab for Colorectal Carcinomatosis | November 4, 2015 | November 9, 2023 |
| NCT02567253 | Completed | Phase 2 | Intraoperative Intraperitoneal Chemoperfusion to Treat Peritoneal Minimal Residual Disease in Stage III Ovarian Cancer | March 2016 | August 25, 2021 |
| NCT02949791 | Completed | Phase 2 | HIPEC Using High Intra-abdominal Pressure | December 2014 | November 2017 |
| NCT04122937 | Completed | Defining Inflammation Related to Peritoneal Carcinomatosis in Women With Ovarian or Colon Cancer. | March 1, 2017 | March 30, 2019 | |
| NCT01826227 | Completed | N/A | Intraoperative Detection of Lesions Using PET (Positron Emission Tomography) Probe During Secondary Cytoreductive Surgery for Recurrent Ovarian, Fallopian Tube and Primary Peritoneal Cancer | March 2013 | December 2016 |
| NCT03188432 | Completed | Phase 2 | Hyperthermic Intraperitoneal Chemotherapy Trial Comparing Quality of Life in Patients With Stage IIIC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | October 13, 2017 | February 8, 2024 |
| NCT05633199 | Not yet recruiting | N/A | Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancer | December 1, 2022 | January 1, 2028 |
| NCT06292286 | Recruiting | N/A | Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer | November 1, 2023 | July 1, 2026 |
| NCT03127774 | Recruiting | Phase 2 | Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma | September 22, 2017 | December 2025 |
| NCT05001880 | Recruiting | Phase 2 | Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma | March 22, 2022 | August 20, 2025 |
| NCT05123807 | Recruiting | Phase 2 | Secondary Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Recurrent Mucinous Ovarian Cancer (HI-MOC Study) | January 7, 2022 | February 2, 2027 |
| NCT05415709 | Recruiting | Early Phase 1 | Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer | June 13, 2022 | December 31, 2024 |
| NCT05431530 | Recruiting | Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer | June 22, 2022 | May 31, 2027 | |
| NCT05610826 | Recruiting | Phase 1/Phase 2 | Preoperative PRRT Versus Surgical Cytoreduction in Metastatic Pancreatic Neuroendocrine Tumors to the Liver | March 7, 2023 | February 1, 2027 |
| NCT06223763 | Recruiting | SUROVA - Surgery in Ovarian Cancer, Comparing Primary and Interval Cytoreductive Surgery | January 1, 2024 | June 1, 2024 | |
| NCT04213794 | Recruiting | Early Phase 1 | Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients | November 8, 2019 | January 30, 2025 |
| NCT04727242 | Recruiting | Phase 2 | CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma | January 28, 2021 | January 2025 |
| NCT00331422 | Terminated | Phase 2 | Carboplatin, Paclitaxel, and Surgery in Treating Patients With Advanced Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer | October 2005 | March 2009 |
| NCT03023436 | Unknown status | Phase 3 | Cytoreductive Surgery Combined With HIPEC and Chemotherapy for Gastric Cancer With Peritoneal Metastasis | January 2016 | June 2022 |
| NCT03373058 | Unknown status | Phase 3 | Efficacy of HIPEC in the Treatment of Advanced-Stage Epithelial Ovarian Cancer After Cytoreductive Surgery | October 15, 2019 | July 1, 2023 |
| NCT03006939 | Unknown status | Fluid Balance During Surgery for Ovarian Cancer | December 2016 | December 2022 | |
| NCT00454519 | Unknown status | Phase 2 | Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis | March 2007 | |
| NCT05375825 | Withdrawn | Phase 1 | Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin | January 31, 2024 | January 31, 2024 |