chr7:55086794:> Detail (hg19) (EGFR)

Information

Genome

Assembly Position
hg19 chr7:55,086,794-55,279,321
hg38 chr7:55,019,101-55,211,628 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
lung adenocarcinoma B Prognostic Supports Better Outcome Somatic 4 22810899 Detail
lung non-small cell carcinoma Afatinib B Predictive Supports Sensitivity/Response Somatic 4 27083334 Detail
lung non-small cell carcinoma Gefitinib B Predictive Supports Sensitivity/Response Somatic 5 20022809 Detail
lung non-small cell carcinoma Gefitinib,Erlotinib B Predictive Supports Sensitivity/Response Somatic 4 21258250 Detail
lung non-small cell carcinoma Gefitinib C Predictive Supports Sensitivity/Response Somatic 19692680 Detail
lung non-small cell carcinoma Afatinib C Predictive Supports Sensitivity/Response Somatic 22452896 Detail
lung non-small cell carcinoma Gefitinib B Predictive Supports Sensitivity/Response Somatic 3 15329413 Detail
lung cancer Gefitinib B Predictive Supports Sensitivity/Response Somatic 2 17409929 Detail
lung non-small cell carcinoma Gefitinib B Predictive Supports Sensitivity/Response 3 20038723 Detail
lung adenocarcinoma B Prognostic Supports Better Outcome Somatic 3 21969500 Detail
lung non-small cell carcinoma Erlotinib B Predictive Supports Sensitivity/Response Somatic 3 15329413 Detail
lung non-small cell carcinoma Erlotinib C Predictive Supports Sensitivity/Response Somatic 4 21969500 Detail
peritoneal mesothelioma Cytoreductive Surgery,Hyperthermic Intraperitoneal Chemotherapy B Predictive Supports Sensitivity/Response Somatic 4 20942962 Detail
lung non-small cell carcinoma Erlotinib B Predictive Supports Sensitivity/Response Somatic 4 21783417 Detail
lung non-small cell carcinoma Dacomitinib B Predictive Supports Sensitivity/Response Somatic 4 28958502 Detail
DisGeNET
[No Data.]
Annotation

Annotations

DescrptionSourceLinks
In a study of 1036 patients with lung adenocarcinomas, patients with EGFR mutations (n=275) showed b... CIViC Evidence Detail
In the LUX-LUNG 7 trial, (NCT01466660) stage IIIB or IV NSCLC patients with EGFR exon 19 deletion, (... CIViC Evidence Detail
This open label Phase 3 Trial performed across 36 centers in Japan (WJTOG3405) assessed patients wit... CIViC Evidence Detail
In a retrospective study, 166 non-small cell lung cancer (NSCLC) patients that tended to have select... CIViC Evidence Detail
In a phase 3 clinical trial of East Asian advanced pulmonary adenocarcinoma patients, a subset of pa... CIViC Evidence Detail
In a phase 2b/3 study of 585 stage IIIB-IV lung adenocarcinoma patients who had a previous round of ... CIViC Evidence Detail
Mutational profiling was performed on EGFR exons 18-24 from a group of 10 retrospectively chosen pat... CIViC Evidence Detail
In a study of 52 patients with recurrent lung cancer, 27 individuals had EGFR mutation including 2 p... CIViC Evidence Detail
In a phase 3 clinical trial of non-small cell lung cancer (NSCLC) patients, a subset of patients wit... CIViC Evidence Detail
Analysis was performed on the placebo group (n=451) of the Phase III study SATURN using erlotinib ma... CIViC Evidence Detail
In a phase II trial for Bronchioloalveolar carcinoma (BAC, or in situ pulmonary adenocarcinoma), EGF... CIViC Evidence Detail
In the placebo-controlled Phase III study SATURN, using erlotinib maintenance therapy for patients w... CIViC Evidence Detail
25 patients with metastatic peritoneal mesothelioma were treated with surgical cytoreduction consoli... CIViC Evidence Detail
In this open-label, randomised, phase 3 trial at 22 centres in China, patients with stage IIIB or IV... CIViC Evidence Detail
In the ARCHER 1050 Phase 3 Trial (NCT01774721), 452 patients with newly diagnosed stage IIIB/IV or r... CIViC Evidence Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
Genome
hg19
Position
chr7:55,086,794-55,279,321
Variant Type
snv
Variant (CIViC) (CIViC Variant)
MUTATION
Transcript 1 (CIViC Variant)
ENST00000275493.2
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/442
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