Apitolisib

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Information
Drug Name
Apitolisib
Description
Entry(CIViC)
3
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
head and neck squamous cell carcinoma PIK3CA p.Glu542Lys (p.E542K)
( ENST00000643187.1, ENST00000263967.4 ) PIK3CA p.Glu542Lys (p.E542K)
( ENST00000263967.4, ENST00000643187.1 ) 		C Predictive Supports Sensitivity/Response Somatic 2 26787751 Detail
cancer PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) 		C Predictive Supports Sensitivity/Response Somatic 1 26787751 Detail
malignant mesothelioma BAP1 ALTERNATIVE TRANSCRIPT (ATI) BAP1 ALTERNATIVE TRANSCRIPT (ATI) D Predictive Supports Sensitivity/Response Somatic 3 28389374 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
Phase 1 study with the dual PI3K/mTOR inhibitor ap... PIK3CA PIK3CA p.Glu542Lys (p.E542K)
( ENST00000643187.1, ENST00000263967.4 ) PIK3CA p.Glu542Lys (p.E542K)
( ENST00000263967.4, ENST00000643187.1 ) 		Sensitivity true CIViC Evidence detail
Phase 1 study with the dual PI3K/mTOR inhibitor ap... PIK3CA PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) 		Sensitivity true CIViC Evidence detail
Novel alternative splice isoform of BAP1 (BAP1Δ) t... BAP1 BAP1 ALTERNATIVE TRANSCRIPT (ATI) BAP1 ALTERNATIVE TRANSCRIPT (ATI) Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT01485861 Completed Phase 1/Phase 2 Study of Ipatasertib or Apitolisib With Abiraterone Acetate Versus Abiraterone Acetate in Participants With Castration-Resistant Prostate Cancer Previously Treated With Docetaxel Chemotherapy January 11, 2012 August 31, 2022