Anti-EGFR Monoclonal Antibody

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Information
Drug Name
Anti-EGFR Monoclonal Antibody
Description
Entry(CIViC)
2
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
colorectal cancer MET AMPLIFICATION
( ENST00000318493.11 ) MET AMPLIFICATION
( ENST00000318493.11 ) 		D Predictive Supports Resistance Somatic 3 23729478 Detail
colorectal cancer PIK3CA MUTATION PIK3CA MUTATION B Predictive Supports Resistance Somatic 4 23435830 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
Functional studies show that MET activation confer... MET MET AMPLIFICATION
( ENST00000318493.11 ) MET AMPLIFICATION
( ENST00000318493.11 ) 		Resitance or Non-Reponse true CIViC Evidence detail
A meta-analysis of 8 metastatic colorectal cancer ... PIK3CA PIK3CA MUTATION PIK3CA MUTATION Resitance or Non-Reponse true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT03491709 Unknown status Phase 1 A Preliminary Clinical Study on the Pharmacokinetics and Safety of CDP1 in Patients With Advanced CRC or HNSCC July 1, 2018 December 1, 2019
NCT03713372 Unknown status Phase 2 Safety and Efficacy of SCT200 in Head and Neck Squamous Cell Carcinoma November 28, 2018 May 28, 2020
NCT03744208 Unknown status Phase 2 SCT200 Injection in Patients With Head and Neck Squamous Cell Carcinoma December 30, 2018 May 28, 2020
NCT03881787 Unknown status Phase 1 Clinical Trial to Evaluate Pharmacokinetics,Safety and Immunogenicity of Single Injection of CDP1 to Healthy Volunteers Compared to Erbitux February 27, 2019 December 30, 2019
NCT04508829 Unknown status Phase 2 Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC Resistant to Induction Chemotherapy January 1, 2016 December 1, 2023