semantic dementia
Information
- Disease name
- semantic dementia
- Disease ID
- DOID:0081391
- Description
- "A primary progressive aphasia that is characterized by the progressive, amodal and profound loss of semantic knowledge and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes." [url:https\://pubmed.ncbi.nlm.nih.gov/28019640/]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| MAPT | 17 | 45,894,554 | 46,028,334 | 4 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT06181500 | Active, not recruiting | N/A | Home-Based Exercise in Primary Progressive Aphasia (HEPPA) | April 5, 2023 | August 31, 2024 |
| NCT04881617 | Active, not recruiting | N/A | Treatment for Speech and Language in Primary Progressive Aphasia | July 1, 2017 | June 30, 2024 |
| NCT01623284 | Completed | Phase 1 | PiB PET Scanning in Speech and Language Based Dementias | March 2010 | January 2015 |
| NCT02819700 | Completed | Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI) | January 29, 2013 | January 28, 2018 | |
| NCT00545974 | Completed | Phase 4 | Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia | October 2007 | December 2012 |
| NCT00957710 | Completed | N/A | Language Treatment for Progressive Aphasia | August 2009 | December 2010 |
| NCT04597827 | Completed | Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease | October 16, 2020 | April 27, 2022 | |
| NCT04680130 | Enrolling by invitation | Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders | November 1, 2020 | November 2050 | |
| NCT06218732 | Not yet recruiting | Revealing Engagement Dynamics Among Semantic Dementia Patients | February 2025 | February 2027 | |
| NCT05800028 | Recruiting | Memory and Social Interactions | March 10, 2023 | December 31, 2026 | |
| NCT05184569 | Recruiting | Phase 1 | Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology | April 19, 2022 | September 30, 2026 |
| NCT03174938 | Recruiting | N/A | The Swedish BioFINDER 2 Study | May 15, 2017 | December 31, 2028 |
| NCT03481933 | Recruiting | N/A | Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia | May 16, 2018 | September 2024 |
| NCT02964637 | Unknown status | Diagnosing Frontotemporal Lobar Degeneration | August 2015 | December 2019 |
- Disase is a (Disease Ontology)
- DOID:0081388
- Cross Reference ID (Disease Ontology)
- GARD:10792
- Cross Reference ID (Disease Ontology)
- ORDO:100069
- Exact Synonym (Disease Ontology)
- semantic variant of primary progressive aphasia
- Exact Synonym (Disease Ontology)
- semantic variant PPA
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0030219
- OrphaNumber from OrphaNet (Orphanet)
- 100069