primary progressive aphasia
Information
- Disease name
- primary progressive aphasia
- Disease ID
- DOID:0081388
- Description
- "A frontotemporal dementia that characterized by the progressive onset of language impairments, and gradual deterioration of these abilities over time, associated with atrophy of the language network of the brain, including frontal, temporal, and parietal regions of the left hemisphere. It is caused by a loss of tissue (atrophy) in the area of the brain that is responsible for producing language." [url:https\://pubmed.ncbi.nlm.nih.gov/21325651/, url:https\://pubmed.ncbi.nlm.nih.gov/29392464/, url:https\://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993834/]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05901233 | Active, not recruiting | N/A | Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia | July 10, 2023 | June 30, 2024 |
| NCT05842473 | Active, not recruiting | N/A | Long-term Effect of TMS in Primary Progressive Aphasia | February 1, 2023 | July 31, 2024 |
| NCT05742698 | Active, not recruiting | Phase 2 | Nabilone for Agitation in Frontotemporal Dementia | March 7, 2023 | December 2025 |
| NCT04881617 | Active, not recruiting | N/A | Treatment for Speech and Language in Primary Progressive Aphasia | July 1, 2017 | June 30, 2024 |
| NCT06181500 | Active, not recruiting | N/A | Home-Based Exercise in Primary Progressive Aphasia (HEPPA) | April 5, 2023 | August 31, 2024 |
| NCT04486586 | Active, not recruiting | N/A | Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive Aphasia | April 2013 | April 2025 |
| NCT04187391 | Active, not recruiting | N/A | The Effects of a Multimodal Approach for the Treatment of Primary Progressive Aphasia | January 15, 2020 | July 4, 2024 |
| NCT02928848 | Completed | N/A | Transcranial Direct Current Stimulation for Primary Progressive Aphasia | June 16, 2017 | March 13, 2020 |
| NCT03076671 | Completed | N/A | More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease | March 1, 2017 | December 31, 2020 |
| NCT03371706 | Completed | N/A | Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia | April 3, 2018 | March 23, 2023 |
| NCT03580954 | Completed | N/A | Transcranial Magnetic Stimulation in Primary Progressive Aphasia | February 1, 2018 | March 10, 2020 |
| NCT03728582 | Completed | N/A | Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy | October 10, 2018 | March 30, 2022 |
| NCT03805659 | Completed | N/A | HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms | February 24, 2020 | May 18, 2022 |
| NCT04045990 | Completed | N/A | Network Modulation in Alzheimer's Disease | September 1, 2018 | March 1, 2022 |
| NCT05537688 | Completed | Identification of Graphic Markers of Neurocognitive Disorders (MG) | June 27, 2022 | August 27, 2023 | |
| NCT00957710 | Completed | N/A | Language Treatment for Progressive Aphasia | August 2009 | December 2010 |
| NCT01465360 | Completed | Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center | November 2011 | ||
| NCT01623284 | Completed | Phase 1 | PiB PET Scanning in Speech and Language Based Dementias | March 2010 | January 2015 |
| NCT02439853 | Completed | N/A | Communication Bridge Speech Therapy Research Study | March 2013 | January 2020 |
| NCT02541097 | Completed | N/A | Preventing Language Decline in Dementia | May 2016 | January 31, 2019 |
| NCT02606422 | Completed | N/A | tDCS Intervention in Primary Progressive Aphasia | April 2013 | August 11, 2023 |
| NCT04412083 | Completed | N/A | PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA | July 30, 2020 | September 19, 2023 |
| NCT04431401 | Completed | N/A | rTMS Treatment of Primary Progressive Aphasia | July 1, 2020 | August 31, 2022 |
| NCT04720001 | Completed | Florbetaben PET Imaging in PPA | August 23, 2018 | February 26, 2021 | |
| NCT04726527 | Completed | Clinical Evaluation of Florbetapir in Primary Progressive Aphasia | March 15, 2012 | February 28, 2017 | |
| NCT04939818 | Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders | June 14, 2021 | September 15, 2022 | |
| NCT05525377 | Completed | N/A | Better Living With Non-memory-led Dementia | June 21, 2022 | February 9, 2023 |
| NCT05615922 | Completed | Phase 2 | Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA) | December 24, 2022 | August 14, 2023 |
| NCT05697380 | Completed | N/A | CB3 Pilot (Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia) | June 1, 2021 | July 12, 2023 |
| NCT05860647 | Completed | N/A | Transmagnetic Stimulation Pilot in Primary Progressive Aphasia | October 2, 2023 | May 3, 2024 |
| NCT05978804 | Enrolling by invitation | N/A | Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease | August 10, 2023 | August 10, 2025 |
| NCT05368350 | Enrolling by invitation | Early Phase 1 | Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation | June 1, 2022 | December 30, 2024 |
| NCT06191198 | Not yet recruiting | Phase 2 | Communication Bridge 3 Study | July 15, 2024 | September 2028 |
| NCT06211374 | Not yet recruiting | N/A | Communication Bridge Pilot Study | July 1, 2024 | September 1, 2024 |
| NCT00537004 | Recruiting | Language in Primary Progressive Aphasia | May 2007 | April 2027 | |
| NCT01818661 | Recruiting | Phase 4 | Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech | July 1, 2018 | June 2028 |
| NCT05730023 | Recruiting | N/A | A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931 | February 1, 2023 | February 2026 |
| NCT05741853 | Recruiting | N/A | Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia | May 1, 2023 | November 30, 2027 |
| NCT03313011 | Recruiting | The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech | August 1, 2017 | July 2027 | |
| NCT04046991 | Recruiting | Phase 2 | Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS | August 17, 2020 | June 30, 2025 |
| NCT04566731 | Recruiting | N/A | Treating Primary Progressive Aphasia (PPA) Using tDCS | December 1, 2020 | July 2024 |
| NCT04920318 | Recruiting | N/A | Enhancing Language Function in Primary Progressive Aphasia | August 30, 2021 | June 15, 2026 |
| NCT04957537 | Recruiting | N/A | Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia | September 20, 2021 | September 2025 |
| NCT05386394 | Recruiting | Phase 2 | Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | February 13, 2024 | February 1, 2028 |
| NCT05443633 | Recruiting | N/A | Enhancing Language Function in Aphasia | October 30, 2022 | December 15, 2028 |
| NCT03887481 | Recruiting | N/A | Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA | October 15, 2022 | October 31, 2027 |
| NCT02736695 | Recruiting | N/A | Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia | July 2016 | June 1, 2030 |
| NCT04290988 | Suspended | N/A | Circuitry Assessment and Reinforcement Training Effects on Recovery | September 23, 2020 | September 1, 2025 |
| NCT03153371 | Unknown status | Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks | April 4, 2016 | March 31, 2022 |
- Disase is a (Disease Ontology)
- DOID:9255
- Cross Reference ID (Disease Ontology)
- GARD:8541
- Cross Reference ID (Disease Ontology)
- ORDO:95432
- OrphaNumber from OrphaNet (Orphanet)
- 95432