Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
- AKT1 UNKNOWN
- Source Database
- MMMP
- Description
- Pretreatment pS6 levels correlated with sensitivity to the PI3K inhibitor, LY294002, whereas PI3K and pAkt did not, suggesting that full activation of the PI3K pathway is needed for sensitivity to PI3K inhibition
- MMMP State
- phosphorylated (activated)
- MMMP Molecule
- AKT
- MMMP Molecule Alias
- PKB
- MMMP Relationship
- no relationship with
- MMMP Drug
- LY294002
- MMMP Drug Alias
- AKT inhibitor
- MMMP Model
- 3
- MMMP Reference
- Aziz SA, Clin Cancer Res 2009, 15:3029-36
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| LY294002 | Resitance or Non-Reponse | true |