Annotation Detail
Information
- Associated Genes
- NRAS
- Associated Variants
- NRAS G13D
- Source Database
- MMMP
- Description
- 17-AAG: HSP90 inhibitor. The only patient who had a NRAS mutation (together with wild type BRAF) had a prolonged time to progression of 49 months, which is in excess of what is clinically predicted for metastatic melanoma
- MMMP State
- mut G13D
- MMMP Molecule
- NRAS
- MMMP Molecule Alias
- N-Ras
- MMMP Relationship
- sensitivity to
- MMMP Drug
- 17-AAG
- MMMP Drug Alias
- Tanespimycin (17-allylamino-17-demethoxygeldanamycin)
- MMMP Model
- 5
- MMMP Reference
- Banerji U, Mol Cancer Ther 2008, 7:737-9
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| 17-AAG | Sensitivity | true |