Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT METHYLATION
- Source Database
- MMMP
- Description
- There was only an insignificant difference in the CpG methylation pattern of the MGMT promoter whereas a clear hypermethylation in the body of the gene was observed in fotemustine resistant cells: MGMT gene (not promoter) hypermethylation leads to MGMT overexpression and thus chemoresistance
- MMMP State
- methylated
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Relationship
- resistance to
- MMMP Drug
- Fotemustine
- MMMP Model
- 3
- MMMP Reference
- Christmann M, Int J Cancer 2001, 92:123-9
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Resitance or Non-Reponse | true |